Tislelizumab (Genetical Recombination)



Tislelizumab is a recombinant anti-PD-1 monoclonal antibody, the complementarity-determining regions of which are derived from mouse antibody and other regions are derived from human IgG4. In the H-chain, the amino acid residues are substituted at 6 positions (S226P, E231P, F232V, L233A, D263A, R407K). Tislelizumab is produced in CHO cells. Tislelizumab is a glycoprotein (molecular weight: ca. 147,000) composed of 2 H-chains (γ4-chains) consisting of 445 amino acid residues each and 2 L-chains (κ-chains) consisting of 214 amino acid residues each.

[1858168-59-8]