Tixagevimab (Genetical Recombination)



Tixagevimab is a recombinant anti-SARS-CoV-2 spike protein monoclonal antibody derived from human IgG1. In the H-chain, amino acid residues at positions 240, 241, 258, 260, 262 and 337 are substituted by Phe, Glu, Tyr, Thr, Glu and Ser, respectively. Tixagevimab is produced in Chinese hamster ovary cells. Tixagevimab is a glycoprotein (molecular weight: ca. 149,000) composed of 2 H-chains (γ1-chains) consisting of 461 amino acid residues each and 2 L-chains (κ-chains) consisting of 216 amino acid residues each.

[2420564-02-7]