Trastuzumab Emtansine (Genetical Recombination)



Trastuzumab Emtansine is an antibody-drug-conjugate (molecular weight:ca.151,000) consisting of emtansine attached mainly to ε-amino group of an average of 3.5 Lys residues of Trastuzumab (Genetical Recombination). Emtansine (4-({3-[(3-{[(1S)-2-{[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^10,14.0^3,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy}-1-methyl-2-oxoethyl]methylamino}-3-oxopropyl)sulfanyl]-2,5-dioxopyrrolidin-1-yl}methyl)cyclohexylcarbonyl (C₄₇H₆₂ClN₄O₁₃S； molecular wight: 958.53)) is a maytansinoid DM1 conjugated to a 4-[(2,5-dioxopyrrolidin-1-yl)methyl]cyclohexylcarbonyl linker.

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