Tusamitamab Ravtansine (Genetical Recombination)



Tusamitamab Ravtansine is an antibody-drug-conjugate (molecular weight: ca. 151,000) consisting of an average of 3-4 Ravtansine (4-[(5-{[(2S)-1-{[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^10,14.0^3,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy}-1-oxopropan-2-yl](methyl)amino}-2-methyl-5-oxopentan-2-yl)disulfanyl]butanoyl group (C₄₂H₅₉ClN₃O₁₁S₂; molecular weight: 881.51)), which is composed of maytansinoid DM4 and linker, attached to a recombinant monoclonal antibody via amino group. The antibody moiety is a recombinant anti-carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) monoclonal antibody, in which the complementarity-determining regions are derived from mouse antibody, other regions are derived from human IgG1, and the C-terminal K450 is deleted in the H-chain. The antibody is produced in CHO cells. The protein moiety is a glycoprotein (molecular weight: ca. 147,000) composed of 2 H-chains (γ1-chains) consisting of 449 amino acid residues each and 2 L-chains (κ-chains) consisting of 214 amino acid residues each.

[2254086-60-5]