Vedolizumab (Genetical Recombination)



Vedolizumab is a recombinant humanized monoclonal antibody composed of complementarity-determining regions derived from mouse anti-human α4β7 integrin monoclonal antibody and framework regions and constant regions derived from human IgG1, whose amino acid residues at positions 239 and 241 in the H-chains are substituted by Ala. Vedolizumab is produced in Chinese hamster ovary cells. Vedolizumab is a glycoprotein (molecular weight: ca. 150,000) composed of 2 H-chains (γ1-chains) consisting of 451 amino acid residues each and 2 L-chains (κ-chains) consisting of 219 amino acid residues each.

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