Zeleciment Rostudirsen (Genetical Recombination)



Zeleciment Rostudirsen is an antibody-oligonucleotide-conjugate (molecular weight: ca. 71,000) consisting of Rostudirsen (C₄₂₁H₆₅₅N₁₉₂O₁₃₆P₃₀; molecular weight: 11,510) attached to an average of two lysine residues of the recombinant monoclonal antibody. The antibody moiety is an Fab fragment of recombinant anti-transferrin receptor 1 monoclonal antibody whose complementarity-determining regions are derived from mouse antibody and other regions are derived from human IgG1. In the H-chain, the amino acid residue is substituted at 1 position (L114T). The protein moiety is produced in CHO cells and is composed of 1 H-chain (γ1-chain) consisting of 227 amino acid residues and 1 L-chain (κ-chain) consisting of 214 amino acid residues.

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