Ziltivekimab (Genetical Recombination)



Ziltivekimab is a recombinant anti-interleukin-6 monoclonal antibody derived from human IgG1. In the H-chain, the amino acid residues are substituted at 3 positions (M255Y, S257T, T259E). Ziltivekimab is produced in CHO cells. Ziltivekimab is a glycoprotein (molecular weight: ca.148,000) composed of 2 H-chains (γ1-chains) consisting of 450 amino acid residues each and 2 L-chains (κ-chains) consisting of 213 amino acid residues each.

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