フィツシランナトリウム
Fitusiran Sodium


all-P-ambo-2'-デオキシ-2'-フルオロ-P-チオグアニリル-(3'→5')-2'-O-メチル-P-チオグアニリル-(3'→5')-2'-デオキシ-2'-フルオロウリジリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-デオキシ-2'-フルオロアデニリル-(3'→5')-2'-O-メチルアデニリル-(3'→5')-2'-デオキシ-2'-フルオロシチジリル-(3'→5')-2'-O-メチルアデニリル-(3'→5')-2'-デオキシ-2'-フルオロシチジリル-(3'→5')-2'-デオキシ-2'-フルオロシチジリル-(3'→5')-2'-デオキシ-2'-フルオロアデニリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-デオキシ-2'-フルオロウリジリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-デオキシ-2'-フルオロアデニリル-(3'→5')-2'-O-メチルシチジリル-(3'→5')-2'-デオキシ-2'-フルオロウリジリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-デオキシ-2'-フルオロシチジリル-(3'→5')-2'-O-メチルアデニリル-(3'→5')-2'-デオキシ-2'-フルオロ-3'-アデニル酸水素[(2S,4R)-1-{1-[(2-アセトアミド-2-デオキシ-β-D-ガラクトピラノシル)オキシ]-16,16-ビス({3-[(3-{5-[(2-アセトアミド-2-デオキシ-β-D-ガラクトピラノシル)オキシ]ペンタンアミド}プロピル)アミノ]-3-オキソプロポキシ}メチル)-5,11,18-トリオキソ-14-オキサ-6,10,17-トリアザノナコサン-29-オイル}-4-ヒドロキシピロリジン-2-イル]メチルとall-P-ambo-2'-O-メチル-P-チオウリジリル-(3'→5')-2'-デオキシ-2'-フルオロ-P-チオウリジリル-(3'→5')-2'-O-メチルグアニリル-(3'→5')-2'-デオキシ-2'-フルオロアデニリル-(3'→5')-2'-O-メチルアデニリル-(3'→5')-2'-デオキシ-2'-フルオログアニリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-デオキシ-2'-フルオロアデニリル-(3'→5')-2'-O-メチルアデニリル-(3'→5')-2'-デオキシ-2'-フルオロアデニリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-O-メチルグアニリル-(3'→5')-2'-O-メチルグアニリル-(3'→5')-2'-デオキシ-2'-フルオロウリジリル-(3'→5')-2'-O-メチルグアニリル-(3'→5')-2'-デオキシ-2'-フルオロウリジリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-デオキシ-2'-フルオロアデニリル-(3'→5')-2'-O-メチルアデニリル-(3'→5')-2'-デオキシ-2'-フルオロシチジリル-(3'→5')-2'-O-メチル-P-チオシチジリル-(3'→5')-2'-O-メチル-P-チオアデニリル-(3'→5')-2'-O-メチルグアノシンの二重鎖　四十三ナトリウム塩

43 Sodium salt of duplex of [(2S,4R)-1-{1-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-16,16-bis({3-[(3-{5-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]pentanamido}propyl)amino]-3-oxopropoxy}methyl)-5,11,18-trioxo-14-oxa-6,10,17-triazanonacosan-29-oyl}-4-hydroxypyrrolidin-2-yl]methyl hydrogen all-P-ambo-2'-deoxy-2'-fluoro-P-thioguanylyl-(3'→5')-2'-O-methyl-P-thioguanylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluoro-3'-adenylate and all-P-ambo-2'-O-methyl-P-thiouridylyl-(3'→5')-2'-deoxy-2'-fluoro-P-thiouridylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluoroguanylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-O-methyl-P-thiocytidylyl-(3'→5')-2'-O-methyl-P-thioadenylyl-(3'→5')-2'-O-methylguanosine

C₅₂₀H₆₃₆F₂₁N₁₇₅Na₄₃O₃₀₉P₄₃S₆  : 17193.39
[1609016-97-8]

ギボシランナトリウム
Givosiran Sodium


all-P-ambo-2'-O-メチル-P-チオシチジリル-(3'→5')-2'-O-メチル-P-チオアデニリル-(3'→5')-2'-O-メチルグアニリル-(3'→5')-2'-O-メチルアデニリル-(3'→5')-2'-O-メチルアデニリル-(3'→5')-2'-O-メチルアデニリル-(3'→5')-2'-デオキシ-2'-フルオログアニリル-(3'→5')-2'-O-メチルアデニリル-(3'→5')-2'-デオキシ-2'-フルオログアニリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-デオキシ-2'-フルオログアニリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-デオキシ-2'-フルオロシチジリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-デオキシ-2'-フルオロシチジリル-(3'→5')-2'-O-メチルアデニリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-O-メチルシチジリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-O-メチル-3'-アデニル酸水素[(2S,4R)-1-{1-[(2-アセトアミド-2-デオキシ-β-D-ガラクトピラノシル)オキシ]-16,16-ビス({3-[(3-{5-[(2-アセトアミド-2-デオキシ-β-D-ガラクトピラノシル)オキシ]ペンタンアミド}プロピル)アミノ]-3-オキソプロポキシ}メチル)-5,11,18-トリオキソ-14-オキサ-6,10,17-トリアザノナコサン-29-オイル}-4-ヒドロキシピロリジン-2-イル]メチルとall-P-ambo-2'-O-メチル-P-チオウリジリル-(3'→5')-2'-デオキシ-2'-フルオロ-P-チオアデニリル-(3'→5')-2'-デオキシ-2'-フルオロアデニリル-(3'→5')-2'-デオキシ-2'-フルオログアニリル-(3'→5')-2'-O-メチルアデニリル-(3'→5')-2'-デオキシ-2'-フルオロウリジリル-(3'→5')-2'-O-メチルグアニリル-(3'→5')-2'-デオキシ-2'-フルオロアデニリル-(3'→5')-2'-O-メチルグアニリル-(3'→5')-2'-デオキシ-2'-フルオロアデニリル-(3'→5')-2'-O-メチルシチジリル-(3'→5')-2'-デオキシ-2'-フルオロアデニリル-(3'→5')-2'-O-メチルシチジリル-(3'→5')-2'-デオキシ-2'-フルオロウリジリル-(3'→5')-2'-O-メチルシチジリル-(3'→5')-2'-デオキシ-2'-フルオロウリジリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-デオキシ-2'-フルオロウリジリル-(3'→5')-2'-O-メチルシチジリル-(3'→5')-2'-デオキシ-2'-フルオロウリジリル-(3'→5')-2'-O-メチル-P-チオグアニリル-(3'→5')-2'-O-メチル-P-チオグアニリル-(3'→5')- 2'-O-メチルウリジンの二重鎖　四十三ナトリウム塩

43 Sodium salt of duplex of [(2S,4R)-1-{1-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-16,16-bis({3-[(3-{5-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]pentanamido}propyl)amino]-3-oxopropoxy}methyl)-5,11,18-trioxo-14-oxa-6,10,17-triazanonacosan-29-oyl}-4-hydroxypyrrolidin-2-yl]methyl hydrogen all-P-ambo-2'-O-methyl-P-thiocytidylyl-(3'→5')-2'-O-methyl-P-thioadenylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluoroguanylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluoroguanylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluoroguanylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyl-3'-adenylate and all-P-ambo-2'-O-methyl-P-thiouridylyl-(3'→5')-2'-deoxy-2'-fluoro-P-thioadenylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-deoxy-2'-fluoroguanylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methyl-P-thioguanylyl-(3'→5')-2'-O-methyl-P-thioguanylyl-(3'→5')-2'-O-methyluridine

C₅₂₄H₆₅₁F₁₆N₁₇₃Na₄₃O₃₁₆P₄₃S₆  : 17245.54
[1639325-44-2]

インクリシランナトリウム
Inclisiran Sodium


インクリシランナトリウムは，プロタンパク質転換酵素サブチリシン／ケキシン9型（PCSK9）に対するsiRNA誘導体のナトリウム塩であり，センス鎖の3’末端に3つのGalNAcを含むリガンド部が結合している．siRNA部分は，部分的に化学修飾された21個のヌクレオチド残基からなるセンス鎖及び化学修飾された23個のヌクレオチド残基からなるアンチセンス鎖から構成される2本鎖オリゴヌクレオチドである．

Inclisiran Sodium is a sodium salt of an siRNA derivative targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) covalently linked to a ligand moiety containing three GalNAc at the 3’ end of the sense strand. The siRNA moiety is composed of a duplex oligonucleotide of sense strand consisting of partially chemically modified 21 nucleotide residues and antisense strand consisting of chemically modified 23 nucleotide residues each.

C₅₂₉H₆₆₄F₁₂N₁₇₆Na₄₃O₃₁₆P₄₃S₆  : 17284.72
[1639324-62-1]

パチシランナトリウム
Patisiran Sodium


グアニリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-アデニリル-(3'→5')-アデニリル-(3'→5')-2'-O-メチルシチジリル-(3'→5')-2'-O-メチルシチジリル-(3'→5')-アデニリル-(3'→5')-アデニリル-(3'→5')-グアニリル-(3'→5')-アデニリル-(3'→5')-グアニリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-アデニリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-2'-O-メチルシチジリル-(3'→5')-2'-O-メチルシチジリル-(3'→5')-アデニリル-(3'→5')-2'-O-メチルウリジリル-(3'→5')-チミジリル-(3'→5')-チミジンとチミジリル-(5'→3')-チミジリル-(5'→3')-シチジリル-(5'→3')-アデニリル-(5'→3')-2'-O-メチルウリジリル-(5'→3')-ウリジリル-(5'→3')-グアニリル-(5'→3')-グアニリル-(5'→3')-ウリジリル-(5'→3')-ウリジリル-(5'→3')-シチジリル-(5'→3')-ウリジリル-(5'→3')-シチジリル-(5'→3')-アデニリル-(5'→3')-2'-O-メチルウリジリル-(5'→3')-アデニリル-(5'→3')-アデニリル-(5'→3')-グアニリル-(5'→3')-グアニリル-(5'→3')-ウリジリル-(5'→3')-アデノシンのRNA二重鎖 四十ナトリウム塩

RNA duplex of guanylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-adenylyl-(3'→5')-adenylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-adenylyl-(3'→5')-adenylyl-(3'→5')-guanylyl-(3'→5')-adenylyl-(3'→5')-guanylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-adenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-adenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-thymidylyl-(3'→5')-thymidine with thymidylyl-(5'→3')-thymidylyl-(5'→3')-cytidylyl-(5'→3')-adenylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-uridylyl-(5'→3')-guanylyl-(5'→3')-guanylyl-(5'→3')-uridylyl-(5'→3')-uridylyl-(5'→3')-cytidylyl-(5'→3')-uridylyl-(5'→3')-cytidylyl-(5'→3')-adenylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-adenylyl-(5'→3')-adenylyl-(5'→3')-guanylyl-(5'→3')-guanylyl-(5'→3')-uridylyl-(5'→3')-adenosine

C₄₁₂H₄₈₀N₁₄₈Na₄₀O₂₉₀P₄₀  : 14303.58
[1386913-72-9]

ブトリシランナトリウム
Vutrisiran Sodium


ブトリシランナトリウムは，トランスサイレチン（TTR）に対するsiRNA 誘導体のナトリウム塩であり，センス鎖の3’末端にGalNAc の3 本鎖複合体が結合している．siRNA 部分は，化学修飾された21 個のヌクレオチド残基からなるセンス鎖及び化学修飾された23 個のヌクレオチド残基からなるアンチセンス鎖から構成される2 本鎖オリゴヌクレオチドである．

Vutrisiran Sodium is a sodium salt of an siRNA derivative targeting transthyretin (TTR) covalently linked to a　triantennary GalNAc3 complex at the 3’ end of the sense strand. The siRNA moiety is composed of a duplex oligonucleotide of sense strand consisting of chemically modified 21 nucleotide residues and antisense strand consisting of chemically modified 23 nucleotide residues each.

C₅₃₀H₆₇₂F₉N₁₇₁Na₄₃O₃₂₃P₄₃S₆  : 17289.77
[1867157-35-4 , ブトリシラン]

ジレベシランナトリウム
Zilebesiran Sodium


ジレベシランナトリウムは，アンジオテンシノーゲンに対するsiRNA誘導体のナトリウム塩であり，センス鎖の3’末端に3つのGalNAcを含むリガンド部が結合している．siRNA部分は，化学修飾された21個のヌクレオチド残基からなるセンス鎖及び化学修飾された23個のヌクレオチド残基からなるアンチセンス鎖から構成される2本鎖オリゴヌクレオチドである．

Zilebesiran Sodium is a sodium salt of an siRNA derivative targeting angiotensinogen covalently linked to a ligand moiety containing three GalNAc at the 3’ end of the sense strand. The siRNA moiety is composed of a duplex oligonucleotide of sense strand consisting of chemically modified 21 nucleotide residues and antisense strand consisting of chemically modified 23 nucleotide residues each.

C₅₃₂H₆₇₈F₇N₁₇₇Na₄₃O₃₂₁P₄₃S₆  : 17333.88
[2380166-34-5]